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Hormone Replacement Therapy
for Men

Hormone replacement therapy (HRT) is a treatment used to restore hormone levels in the body when they become imbalanced or decrease due to aging, medical conditions, or specific life stages. For both men and women, there are several options available, each with its benefits and considerations. The most common use of HRT is for managing symptoms of hormonal imbalances, such as those related to low testosterone in men. 

For men, the primary form of hormone replacement therapy is focused on testosterone replacement therapy (TRT).   Men may seek HRT if they have low testosterone levels, a condition known as hypogonadism. Symptoms include fatigue, low libido, mood changes, muscle loss, and reduced bone density.

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 1. Testosterone Injections

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Injectable testosterone is one of the most common methods for delivering TRT. It is typically administered into the muscle (intramuscular injection) once every 1 to 2 weeks, though the frequency may vary.

 

  • Benefits: Provides a high dose of testosterone that helps improve energy, libido, mood, muscle mass, and bone density.

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  • Risks: Blood clots, mood swings, acne, hair loss, and possible worsening of sleep apnea. Some men may experience a "roller-coaster" effect due to fluctuating hormone levels between injections.

 

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 2. Testosterone Pellets

 

Testosterone pellets are implanted under the skin (usually in the hip area) and release testosterone slowly over several months.

 

  • Benefits: Long-lasting with consistent hormone release. Low maintenance, as the pellets typically last 3 to 6 months.

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  • Risks: Infection at the implant site, pellet expulsion, and difficulty adjusting the dose once the pellets are implanted.

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3. Testosterone Gels and Creams

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Testosterone gels or creams are applied to the skin (typically on the shoulders, arms, or abdomen) once daily. The testosterone is absorbed through the skin into the bloodstream.

 

  • Benefits: Convenient and easy to apply. Steady, consistent hormone release.

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  • Risks: Skin irritation, possible transfer of testosterone to others (especially to women and children), and the need for daily application.

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4. Testosterone Patches

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Testosterone patches are worn on the skin, and they release testosterone steadily throughout the day.

 

  • Benefits: Provides a steady, consistent dose of testosterone, reducing the "roller-coaster" effect seen with injections.

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  • Risks: Skin irritation, potential transfer of testosterone to others through skin contact, and possible discomfort.

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 5. Oral Testosterone

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Oral testosterone is available but is generally less commonly prescribed due to concerns about liver toxicity. Newer formulations of oral testosterone have been developed that have fewer side effects on the liver, though they still require careful monitoring.

 

  • Benefits: Convenient method of administration.

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  • Risks: Potential liver damage, increased risk of blood clots, and gastrointestinal discomfort.

 

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6. Transdermal Testosterone Patches

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A more discreet form of TRT, transdermal patches are applied to the skin, typically on the back, stomach, or thigh.

 

  • Benefits: Steady hormone release and ease of use.

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  • Risks: Skin irritation and potential transfer to others.

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